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Macrocycle-Antibiotic Hybrids: A Path to Clinical Candidates

30 Apr 2021

Abstract excerpt

The tale of abate in antibiotics continued defense mechanisms that chaperone the rise of drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and development. Our salvation lies in circumventing the genesis of resistance. Considering the competitive advantages of antibacterial chemotherapeutic agents equipped with multiple warheads against resistance, the development of hybrids has...

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PMID: 33996753
DOI: 10.3389/fchem.2021.659845

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