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Article

Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Dec 2006

Zhao Xilin, Quinn Brian, Kerns Robert, Drlica Karl

Abstract excerpt

BACKGROUND: Previous work showed that piperazinyl-cross-linked ciprofloxacin dimer exhibits good bacteriostatic activity with Streptococcus pneumoniae and Staphylococcus aureus; lethal activity was not measured. Subsequently, the dimer failed to kill Mycobacterium smegmatis but blocked growth. Whether the compound is lethal with non-mycobacterial species is not known. METHODS: Bacteriostatic and bactericidal...

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Source

Identifiers

PMID: 17003060
DOI: 10.1093/jac/dkl388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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