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Article

Efficacy of novel rifamycin derivatives against rifamycin-sensitive and -resistant Staphylococcus aureus isolates in murine models of infection.

Antimicrobial agents and chemotherapy - 1 Nov 2006

Rothstein David M, Farquhar Ronald S, Sirokman Klari, Sondergaard Karen L, Hazlett Charles, Doye Angelia A, Gwathmey Judith K, Mullin Steve, van Duzer John, Murphy Christopher K

Abstract excerpt

Novel rifamycins (new chemical entities [NCEs]) having MICs of 0.002 to 0.03 microg/ml against Staphylococcus aureus and retaining some activity against rifampin-resistant mutants were tested for in vivo efficacy against susceptible and rifampin-resistant strains of S. aureus. Rifalazil and rifampin had a 50% effective dose (ED50) of 0.06 mg/kg of body weight when administered as a single intravenous (i.v.) dose...

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Identifiers

PMID: 16940074
DOI: 10.1128/AAC.01087-05
PMCID: PMC1635239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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