Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway

Abstract excerpt

Neurofibromatosis type I (NF1) is a genetic disorder caused by mutations in the NF1 tumor suppressor gene. Neurofibromin is encoded by NF1 and functions as a negative regulator of Ras activity. Somatic mutations in the residual normal NF1 allele within cancers of NF1 patients is consistent with NF1 functioning as a tumor-suppressor. However, the prevalent non-malignant manifestations of NF1, including learning...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neurofibromatosis and Schwannoma Cases
• Share to Protein Tyrosine Phosphatases
• Share to Sarcoma Diagnosis and Treatment