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Article

Nf1 has an essential role in endothelial cells.

Nature genetics - 1 Jan 2003

Gitler Aaron D, Zhu Yuan, Ismat Fraz A, Lu Min Min, Yamauchi Yasutaka, Parada Luis F, Epstein Jonathan A

Abstract excerpt

Neurofibromatosis type 1 (NF1) or von Recklinghausen neurofibromatosis is a genetic disorder that occurs in 1 of 4000 births and is characterized by benign and malignant tumors. Cardiovascular defects also contribute to NF1, though the pathogenesis is still unclear. Deficiency in neurofibromin (encoded by Nf1) in mice results in mid-embryonic lethality owing to cardiac abnormalities previously thought to be...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12469121
DOI: 10.1038/ng1059
PMCID: PMC3079412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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