Article
Genetic variants promoting smooth muscle cell proliferation can result in diffuse and diverse vascular diseases: evidence for a hyperplastic vasculomyopathy.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Apr 2010
Milewicz Dianna M, Kwartler Callie S, Papke Christina L, Regalado Ellen S, Cao Jiumei, Reid Amy J
Abstract excerpt
Genetic predisposition to early onset of occlusive vascular diseases, including coronary artery disease, ischemic stroke, and Moyamoya disease, may represent varying presentations of a common underlying dysregulation of vascular smooth muscle cell proliferation. We discuss mutations in two genes, NF1 and ACTA2, which predispose affected individuals to diffuse and diverse vascular diseases. These patients show...
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