Article
Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2009
Padmanabhan Arun, Lee Jeong-Soo, Ismat Fraz A, Lu Min Min, Lawson Nathan D, Kanki John P, Look A Thomas, Epstein Jonathan A
Abstract excerpt
Von Recklinghausen neurofibromatosis is a common autosomal dominant genetic disorder characterized by benign and malignant tumors of neural crest origin. Significant progress in understanding the pathophysiology of this disease has occurred in recent years, largely aided by the development of relevant animal models. Von Recklinghausen neurofibromatosis is caused by mutations in the NF1 gene, which encodes...
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