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Article

Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure.

Breast cancer research and treatment - 1 Apr 2009

Costantino Lucia, Catalano Maria G, Frairia Roberto, Carmazzi Carlo M, Barbero Maggiorino, Coluccia Claudio, Donadio Michela, Genta Franco, Drogo Mauro, Boccuzzi Giuseppe, Fortunati Nicoletta

Abstract excerpt

Sex Hormone-Binding Globulin, the specific carrier for sex steroids, regulates hormone bioavailable fraction and estrogen signaling system in breast cancer cells. A common single nucleotide polymorphism in the human SHBG gene results in an amino acid substitution (Asp327Asn), which introduces an additional N-glycosylation site, and is associated with reduced breast cancer risk in postmenopausal women. The...

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PMID: 18437557
DOI: 10.1007/s10549-008-0031-4

Genes

SHBG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure.PMID 18437557Read ↗

Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene.Semantic proximity Read ↗

Association between SHBG Asp327Asn (rs6259) polymorphism and breast cancer risk: a meta-analysis of 10,454 cases and 13,111 controls.Semantic proximity Read ↗

The additionally glycosylated variant of human sex hormone-binding globulin (SHBG) is linked to estrogen-dependence of breast cancer.Semantic proximity Read ↗

Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women.Semantic proximity Read ↗

Sex hormone-binding globulin antagonizes the anti-apoptotic effect of estradiol in breast cancer cells.Semantic proximity Read ↗

Sex hormone-binding globulin provides a novel entry pathway for estradiol and influences subsequent signaling in lymphocytes via membrane receptorSemantic proximity Read ↗

Sex hormone-binding globulin polymorphisms in familial and sporadic breast cancer.Semantic proximity Read ↗

Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene.Semantic proximity Read ↗

O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation.Semantic proximity Read ↗

Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence.Semantic proximity Read ↗

Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome.Semantic proximity Read ↗

New Insights in the Diagnostic Potential of Sex Hormone-Binding Globulin (SHBG)—Clinical ApproachSemantic proximity Read ↗

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