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Article

Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene.

Cancer - 1 Apr 2007

Kataoka Nobuhiko, Cai Qiuyin, Xu Wang Hong, Xiang Yong-Bing, Cai Hui, Zheng Wei, Shu Xiao Ou

Abstract excerpt

BACKGROUND: Sex steroid hormones play a central role in the development of endometrial cancer. Sex hormone-binding globulin (SHBG) modulates the bioavailability of circulating sex hormones and regulates their signaling systems in target cells. Epidemiologic studies have demonstrated that blood SHBG levels are associated inversely with the risk of endometrial cancer. A functional polymorphism, an amino acid...

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Source

Identifiers

PMID: 17315164
DOI: 10.1002/cncr.22531

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene.PMID 17315164Read ↗

Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene.Semantic proximity Read ↗

The Asp(327)Asn polymorphism in the sex hormone-binding globulin gene modifies the association of soy food and tea intake with endometrial cancer risk.Semantic proximity Read ↗

Association between SHBG Asp327Asn (rs6259) polymorphism and breast cancer risk: a meta-analysis of 10,454 cases and 13,111 controls.Semantic proximity Read ↗

Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence.Semantic proximity Read ↗

Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure.Semantic proximity Read ↗

Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis.Semantic proximity Read ↗

The Asn680Ser polymorphism of the follicle stimulating hormone receptor gene and ovarian cancer risk: a meta-analysis.Semantic proximity Read ↗

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Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women.Semantic proximity Read ↗

Functional characterization of seven single-nucleotide polymorphisms of the steroid sulfatase gene found in a Japanese population.Semantic proximity Read ↗

Association of the (TAAAA)n repeat and Asp327Asn polymorphisms in the sex hormone-binding globulin (SHBG) gene with idiopathic male infertility and relation to serum SHBG concentrations.Semantic proximity Read ↗

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