Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex hormone-binding globulin antagonizes the anti-apoptotic effect of estradiol in breast cancer cells.

Molecular and cellular endocrinology - 31 Jan 2005

Catalano M G, Frairia R, Boccuzzi G, Fortunati N

Abstract excerpt

Sex hormone-binding globulin, the plasma carrier for sex steroids, inhibits the estradiol-induced proliferation of breast cancer cells. Estradiol induces cell proliferation triggering multiple mechanisms. Besides regulating growth factors, it activates Erk-1/-2, thus inhibiting apoptosis. In the present study, we investigated the effect of SHBG on estradiol-mediated anti-apoptotic effect in MCF-7 breast cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Breast Neoplasms
Share to Estradiol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Antagonists

Share to Glycosylation

Share to Mitogen-Activated Protein Kinase 3

Share to Phosphorylation

Share to Sex Hormone-Binding Globulin

Source

Identifiers

PMID: 15664449
DOI: 10.1016/j.mce.2004.11.005

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex hormone-binding globulin antagonizes the anti-apoptotic effect of estradiol in breast cancer cells.PMID 15664449Read ↗

Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure.Semantic proximity Read ↗

O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation.Semantic proximity Read ↗

Sex hormone-binding globulin provides a novel entry pathway for estradiol and influences subsequent signaling in lymphocytes via membrane receptorSemantic proximity Read ↗

Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt.Semantic proximity Read ↗

Exposure to EGF and 17β‑estradiol irreversibly affects the proliferation and transformation of MCF7 cells but is not sufficient to promote tumor growth in a xenograft mouse model upon withdrawal of exposure.Semantic proximity Read ↗

Antiestrogens induce growth inhibition by sequential activation of p38 mitogen-activated protein kinase and transforming growth factor-beta pathways in human breast cancer cells.Semantic proximity Read ↗

The additionally glycosylated variant of human sex hormone-binding globulin (SHBG) is linked to estrogen-dependence of breast cancer.Semantic proximity Read ↗

17β-Estradiol Inhibits Apoptosis in MCF-7 Cells, Inducing <i>bcl-2</i> Expression via Two Estrogen-Responsive Elements Present in the Coding SequenceSemantic proximity Read ↗

Estradiol Up-Regulates Antiapoptotic Bcl-2 Messenger Ribonucleic Acid and Protein in Tumorigenic Ovarian Surface Epithelium Cells*Semantic proximity Read ↗

Normal breast epithelial cells induce apoptosis of MCF-7 breast cancer cells through a p53-mediated pathway.Semantic proximity Read ↗

Differences between human breast cell lines in susceptibility towards growth inhibition by genisteinSemantic proximity Read ↗

Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.