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Article

Sex hormone-binding globulin polymorphisms in familial and sporadic breast cancer.

Carcinogenesis - 1 Aug 2002

Försti Asta, Jin Qianren, Grzybowska Ewa, Söderberg Magnus, Zientek Helena, Sieminska Marzena, Rogozinska-Szczepka Jadwiga, Chmielik Ewa, Utracka-Hutka Beata, Hemminki Kari

Abstract excerpt

Ovarian steroids are one of the strongest risk factors for breast cancer. Sex hormone-binding globulin (SHBG) binds and transports sex steroids in the blood, regulating their bioavailable fraction and access to target cells. It can also inhibit the estradiol-induced proliferation of breast cancer cells through its membrane receptor. Three coding-region polymorphisms, which lead to an amino acid change, have been...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12151349
DOI: 10.1093/carcin/23.8.1315

Genes

BRCA1
BRCA2
SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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