Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The additionally glycosylated variant of human sex hormone-binding globulin (SHBG) is linked to estrogen-dependence of breast cancer.

Breast cancer research and treatment - 1 Mar 1999

Becchis M, Frairia R, Ferrera P, Fazzari A, Ondei S, Alfarano A, Coluccia C, Biglia N, Sismondi P, Fortunati N

Abstract excerpt

Sex Hormone-Binding Globulin (SHBG), the plasma carrier for androgens and estradiol, inhibits the estradiol-induced proliferation of breast cancer cells through its membrane receptor, cAMP, and PKA. In addition, the SHBG membrane receptor is preferentially expressed in estrogen-dependent (ER+/PR+) breast cancers which are also characterized by a lower proliferative rate than tumors negative for the SHBG receptor....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Asparagine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast

Share to Cell Division

Share to Estradiol

Share to Glycosylation

Share to Reference Values

Share to Sex Hormone-Binding Globulin

Source

Identifiers

PMID: 10424400
DOI: 10.1023/a:1006100929670

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The additionally glycosylated variant of human sex hormone-binding globulin (SHBG) is linked to estrogen-dependence of breast cancer.PMID 10424400Read ↗

Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure.Semantic proximity Read ↗

Sex hormone binding globulin phenotypes: their detection and distribution in healthy adults and in different clinical conditions.Semantic proximity Read ↗

Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women.Semantic proximity Read ↗

O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation.Semantic proximity Read ↗

Association between SHBG Asp327Asn (rs6259) polymorphism and breast cancer risk: a meta-analysis of 10,454 cases and 13,111 controls.Semantic proximity Read ↗

Sex hormone-binding globulin polymorphisms in familial and sporadic breast cancer.Semantic proximity Read ↗

Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women.Semantic proximity Read ↗

Sex Hormone-Binding Globulin: Gene Organization and Structure/Function AnalysesSemantic proximity Read ↗

Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene.Semantic proximity Read ↗

Detection of a MspI restriction fragment length polymorphism for the human sex hormone-binding globulin (SHBG) gene.Semantic proximity Read ↗

Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit.Semantic proximity Read ↗

Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.