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Article

Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome.

The Journal of steroid biochemistry and molecular biology - 1 Apr 2007

Bendlová Bela, Zavadilová Jana, Vanková Markéta, Vejrazková Daniela, Lukásová Petra, Vcelák Josef, Hill Martin, Cibula David, Vondra Karel, Stárka Luboslav, Vrbíková Jana

Abstract excerpt

SHBG (sex hormone-binding globulin) is a transport protein specific for dihydrotestosterone, testosterone and estradiol. The missense mutation in exon 8 (GAC-->AAC) causing the amino acid exchange Asp-->Asn in codon 327 (D327N) correlates according to the published data with increased SHBG levels. We studied possible association of this polymorphism with polycystic ovary syndrome (PCOS) and anthropometric and...

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Identifiers

PMID: 17258903
DOI: 10.1016/j.jsbmb.2006.10.002

Genes

SHBG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome.PMID 17258903Read ↗

Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome.Semantic proximity Read ↗

Association of anthropometric, androgenic and insulin-related features with polymorphisms in exon 8 of SHBG gene in women with polycystic ovary syndrome.Semantic proximity Read ↗

Association of the Genetic Polymorphisms rs6259 and rs727428 of the SHBG Gene with Polycystic Ovary Syndrome Risk: A Meta-Analysis.Semantic proximity Read ↗

Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis.Semantic proximity Read ↗

Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women.Semantic proximity Read ↗

Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women.Semantic proximity Read ↗

Association between the (TAAAA)n SHBG polymorphism and PCOS: a systematic review and meta-analysis.Semantic proximity Read ↗

The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome.Semantic proximity Read ↗

Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome.Semantic proximity Read ↗

Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men.Semantic proximity Read ↗

Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene.Semantic proximity Read ↗

Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels.Semantic proximity Read ↗

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