Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation.

Molecular and cellular endocrinology - 28 Mar 2002

Raineri M, Catalano M G, Hammond G L, Avvakumov G V, Frairia R, Fortunati N

Abstract excerpt

Human sex hormone-binding globulin (SHBG) is a homodimeric plasma glycoprotein, and each SHBG monomer may have an O-linked oligosaccharide at Thr(7) and up to two N-linked oligosaccharides at Asn(351) and Asn(367). In addition, a common genetic variant of SHBG exists with an extra site for N-glycosylation at residue 327. In the present study, we isolated MCF-7 derived cell lines expressing human SHBG cDNAs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Culture Media, Conditioned

Share to Estradiol

Share to Glycosylation

Share to Protein Binding

Share to Sex Hormone-Binding Globulin

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12039072
DOI: 10.1016/s0303-7207(01)00725-0

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation.PMID 12039072Read ↗

Sex hormone-binding globulin antagonizes the anti-apoptotic effect of estradiol in breast cancer cells.Semantic proximity Read ↗

Molecular mechanisms of the D327N SHBG protective role on breast cancer development after estrogen exposure.Semantic proximity Read ↗

The additionally glycosylated variant of human sex hormone-binding globulin (SHBG) is linked to estrogen-dependence of breast cancer.Semantic proximity Read ↗

Sex Hormone-Binding Globulin: Gene Organization and Structure/Function AnalysesSemantic proximity Read ↗

Control of cell proliferation of human breast MCF7 cells; serum and estrogen resistant variants.Semantic proximity Read ↗

The role of the asparagine-linked oligosaccharides of the alpha-subunit in human thyrotropin bioactivity.Semantic proximity Read ↗

Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation.Semantic proximity Read ↗

Site-directed mutagenesis of heparin-binding EGF-like growth factor (HB-EGF): analysis of O-glycosylation sites and properties.Semantic proximity Read ↗

Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit.Semantic proximity Read ↗

Tamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.