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Article

Absence of Glaucoma in Tg-MYOCY437H Mice of Diverse Genetic Backgrounds.

Investigative ophthalmology & visual science - 2 Sept 2025

Tolman Nicholas G, Simón Marina, Juarez Felicia A, Zhang Chi, Hristova Zhivka I, Ouellette Tionna B, Sellarole Michael A, deVries Wilhelmine N, Montgomery Christa, John Simon W M

Abstract excerpt

Purpose: Mutations in the myocilin (MYOC) gene cause elevated intraocular pressure and glaucoma. To better understand the factors influencing susceptibility to glaucoma, we studied the MYOC mutation (MYOCY437H). Methods: We characterized ocular phenotypes in Tg-MYOCY437H mice on nine different mouse strain backgrounds. Results: No glaucoma-related phenotypes were observed. We detected neither elevated intraocular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40965407
DOI: 10.1167/iovs.66.12.40
PMCID: PMC12449821

Genes

MYOC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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