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Article

Type-I but not type-II interferon receptor knockout mice are susceptible to biliary atresia.

Pediatric research - 1 Jun 2006

Kuebler Joachim F, Czech-Schmidt Gerard, Leonhardt Johannes, Ure Benno M, Petersen Claus

Abstract excerpt

The etiology of biliary atresia (BA) is not yet understood, but recent studies have shown inflammation with an up-regulated interferon (IFN) activity in the intra- and extrahepatic bile ducts of patients with BA. These findings support an inflammatory/infectious cause of BA as mimicked in our infective murine model. To study the role of the IFN receptors in our model, we used mice with inactivated INF-alpha/beta...

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Identifiers

PMID: 16641200
DOI: 10.1203/01.pdr.0000219860.96732.09

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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