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Article

Determinants of the specificity of rotavirus interactions with the alpha2beta1 integrin.

The Journal of biological chemistry - 25 Feb 2011

Fleming Fiona E, Graham Kate L, Takada Yoshikazu, Coulson Barbara S

Abstract excerpt

The human α2β1 integrin binds collagen and acts as a cellular receptor for rotaviruses and human echovirus 1. These ligands require the inserted (I) domain within the α2 subunit of α2β1 for binding. Previous studies have identified the binding sites for collagen and echovirus 1 in the α2 I domain. We used CHO cells expressing mutated α2β1 to identify amino acids involved in binding to human and animal...

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Identifiers

PMID: 21138834
DOI: 10.1074/jbc.M110.142992
PMCID: PMC3057834

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Source receipt: pubmed, retrieved 7 Sept 2026.

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