Article
Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates.
Pediatric research - 1 Jul 2017
Carey Alexandra N, Zhang Wujuan, Setchell Kenneth D R, Simmons Julia R, Shi Tiffany, Lages Celine S, Mullen Mary, Carroll Kaitlin, Karns Rebekah, Bessho Kazuhiko, Sheridan Rachel, Zhao Xueheng, Weber Susanne N, Miethke Alexander G
Abstract excerpt
BackgroundHeterozygous mutations in the gene ABCB4, encoding the phospholipid floppase MDR3 (Mdr2 in mice), are associated with various chronic liver diseases. Here we hypothesize that reduced ABCB4 expression predisposes to extrahepatic biliary atresia (EHBA).MethodsLivers from neonatal wild-type (wt) and heterozygous Mdr2-deficient mice were subjected to mass spectrometry-based lipidomics and RNA sequencing...
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