Article
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide.
Structure (London, England : 1993) - 15 May 1998
Xue Y, Björquist P, Inghardt T, Linschoten M, Musil D, Sjölin L, Deinum J
Abstract excerpt
BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) is an important endogenous regulator of the fibrinolytic system. Reduction of PAI-1 activity has been shown to enhance dissolution of blood clots. Like other serpins, PAI-1 binds covalently to a target serine protease, thereby irreversibl...
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