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Article

Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects.

Prenatal diagnosis - 1 Jun 2008

Brouns R, Ursem N, Lindemans J, Hop W, Pluijm S, Steegers E, Steegers-Theunissen R

Abstract excerpt

OBJECTIVE: To investigate the associations between biomarkers and genetic variants involved in homocysteine metabolism and the risk of complex birth defects. METHODS: Total homocysteine (tHcy), folate, cobalamin, apo-transcobalamin (apo-TC) and apo-haptocorrin (apo-HC) were measured in the amniotic fluid of 82 women who were pregnant with a child having a complex birth defect, such as neural tube defect, cleft...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18435414
DOI: 10.1002/pd.2006

Genes

MTHFR
MTR
MTRR
TCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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