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Article

Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease.

Journal of neuropathology and experimental neurology - 1 May 2008

Basurto-Islas Gustavo, Luna-Muñoz Jose, Guillozet-Bongaarts Angela L, Binder Lester I, Mena Raul, García-Sierra Francisco

Abstract excerpt

Truncations of tau protein at aspartic acid421 (D421) and glutamic acid391 (E391) residues are associated with neurofibrillary tangles (NFTs) in the brains of Alzheimer disease (AD) patients. Using immunohistochemistry with antibodies to D421- and E391-truncated tau (Tau-C3 and MN423, respectively), we correlated the presence of NFTs composed of these truncated tau proteins with clinical and neuropathologic...

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Identifiers

PMID: 18431250
DOI: 10.1097/NEN.0b013e31817275c7
PMCID: PMC4699801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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