Article

The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer’s Disease

2025-06-06

Abstract excerpt

Neurofibrillary tangles are dynamic neuropathologic hallmarks of Alzheimer’s disease with a hypothesized lifespan morphologically-defined by three maturity levels: pretangles, mature tangles, and ghost tangles. To better understand the progression of tangle pathophysiology, we characterized tangle maturity level predilection of 15 tau antibodies recognizing a broad range of linear, phosphorylation, conformational,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64f309d0-cb5e-507c-a157-0b435a2259ad
DOI: 10.1101/2025.06.02.657435

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer’s DiseaseDOI 10.1101/2025.06.02.657435Read

Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer’s disease brainSemantic proximity Read

Advances in Deep Neuropathological Phenotyping of Alzheimer Disease: Past, Present, and Future.Semantic proximity Read

Pretangles and neurofibrillary changes: Similarities and differences between AD and CBD based on molecular and morphological evolutionSemantic proximity Read

Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer’s diseaseSemantic proximity Read

Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.Semantic proximity Read

Machine Learning Classification of Alzheimer’s Disease Pathology Reveals Diffuse Amyloid as a Major Predictor of Cognitive Impairment in Human Hippocampal SubregionsSemantic proximity Read

Generalizable Prediction of Alzheimer Disease Pathologies with a Scalable Annotation Tool and an High-Accuracy ModelSemantic proximity Read

A Scalable High Throughput Fully Automated Pipeline for the Quantification of Amyloid Pathology in Alzheimer’s Disease using Deep Learning AlgorithmsSemantic proximity Read

Protocols for assessing neurodegenerative phenotypes in Alzheimer's mouse models.Semantic proximity Read

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotationsSemantic proximity Read

The utility of medial temporal lobe atrophy (MTA) grading as a practical method for assessing tau pathology and neurodegeneration in early-stage Alzheimer’s diseaseSemantic proximity Read

Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementiaSemantic proximity Read