Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety.

Molecular psychiatry - 1 Sept 2009

Chiavegatto S, Izidio G S, Mendes-Lana A, Aneas I, Freitas T A, Torrão A S, Conceição I M, Britto L R G, Ramos A

Abstract excerpt

A genomic region neighboring the alpha-synuclein gene, on rat chromosome 4, has been associated with anxiety- and alcohol-related behaviors in different rat strains. In this study, we have investigated potential molecular and physiological links between alpha-synuclein and the behavioral differences observed between Lewis (LEW) and Spontaneously Hypertensive (SHR) inbred rats, a genetic model of anxiety. As...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Anxiety

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine

Share to Exploratory Behavior

Share to Maze Learning

Share to PC12 Cells

Share to Rats, Inbred Lew

Share to Rats, Inbred SHR

Source

Identifiers

PMID: 18427558
DOI: 10.1038/mp.2008.43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety.PMID 18427558Read ↗

alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats.Semantic proximity Read ↗

Alpha-synuclein transgenic mice exhibit reduced anxiety-like behaviour.Semantic proximity Read ↗

Ethanol (EtOH)-Related Behaviors in α-Synuclein Mutant Mice and Association of SNCA SNPs with Anxiety in EtOH-Dependent Patients.Semantic proximity Read ↗

Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring rats.Semantic proximity Read ↗

α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotionSemantic proximity Read ↗

Sex-specific pleiotropic changes in emotional behavior and alcohol consumption in human α-synuclein A53T transgenic mice during early adulthood.Semantic proximity Read ↗

Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons.Semantic proximity Read ↗

Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior.Semantic proximity Read ↗

The role of α-synuclein in the pathophysiology of alcoholism.Semantic proximity Read ↗

Enhanced motivation to alcohol in transgenic mice expressing human α-synuclein.Semantic proximity Read ↗

Neuronal expression of familial Parkinson's disease A53T α-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice.Semantic proximity Read ↗

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.