Article
RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.
European journal of endocrinology - 1 May 2008
Herder Christian, Illig Thomas, Baumert Jens, Müller Martina, Klopp Norman, Khuseyinova Natalie, Meisinger Christa, Poschen Ulrike, Martin Stephan, Koenig Wolfgang, Thorand Barbara
Abstract excerpt
OBJECTIVE: Regulated on activation, normal T-cell expressed and secreted (RANTES)/chemokine(C-C motif) ligand (CCL5) is expressed by adipocytes, and serum levels of RANTES are increased in obesity and type 2 diabetes. The aim of this study was to test the hypothesis that RANTES is involved in the pathogenesis of type 2 diabetes by analyzing the triangular association between CCL5 gene polymorphisms, systemic...
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