Article
Chemotactic cytokine receptor 5 (CCR5) gene promoter polymorphism (59029A/G) is associated with diabetic nephropathy in Japanese patients with type 2 diabetes: a 10-year longitudinal study.
Diabetes research and clinical practice - 1 Jul 2006
Mokubo Atsuko, Tanaka Yasushi, Nakajima Kunihiro, Watada Hirotaka, Hirose Takahisa, Kawasumi Masahiko, Sakai Ken, Kanazawa Akio, Maeda Shiro, Hosokawa Kazuhiro, Atsumi Yoshihito, Matsuoka Kenpei, Kawamori Ryuzo
Abstract excerpt
We previously showed that polymorphisms of the promoter area of chemokine receptor 5 (CCR5) gene (59029G/A) and its agonist, regulated upon activation, normal T-cell expressed and secreted (RANTES) gene (-28C/G) were new candidates for susceptibility to diabetic nephropathy. The aim of this study was to confirm the effect of these polymorphisms on the development and progression of diabetic nephropathy. We...
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