Article
RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies.
PloS one - 1 Jan 2011
Herder Christian, Peeters Wouter, Illig Thomas, Baumert Jens, de Kleijn Dominique P V, Moll Frans L, Poschen Ulrike, Klopp Norman, Müller-Nurasyid Martina, Roden Michael, Preuss Michael, Karakas Mahir, Meisinger Christa, Thorand Barbara, Pasterkamp Gerard, Koenig Wolfgang, Assimes Themistocles L, Deloukas Panos, Erdmann Jeanette, Holm Hilma, Kathiresan Sekar, König Inke R, McPherson Ruth, Reilly Muredach P, Roberts Robert, Samani Nilesh J, Schunkert Heribert, Stewart Alexandre F R
Abstract excerpt
BACKGROUND: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary...
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