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Article

Methylation alterations are not a major cause of PTTG1 misregulation.

BMC cancer - 21 Apr 2008

Hidalgo Manuel, Galan Jose Jorge, Sáez Carmen, Ferrero Eduardo, Castilla Carolina, Ramirez-Lorca Reposo, Pelaez Pablo, Ruiz Agustin, Japón Miguel A, Royo Jose Luis

Abstract excerpt

BACKGROUND: On its physiological cellular context, PTTG1 controls sister chromatid segregation during mitosis. Within its crosstalk to the cellular arrest machinery, relies a checkpoint of integrity for which gained the over name of securin. PTTG1 was found to promote malignant transformation in 3T3 fibroblasts, and further found to be overexpressed in different tumor types. More recently, PTTG1 has been also...

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Source

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Identifiers

PMID: 18426563
DOI: 10.1186/1471-2407-8-110
PMCID: PMC2377271

Genes

PTTG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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