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Article

Intrinsic LINE-1 Hypomethylation and Decreased Brca1 Expression are Associated with DNA Repair Delay in Irradiated Thyroid Cells.

Radiation research - 1 Aug 2017

Penha Ricardo Cortez Cardoso, Lima Sheila Coelho Soares, Boroni Mariana, Ramalho-Oliveira Renata, Viola João P, de Carvalho Denise Pires, Fusco Alfredo, Pinto Luis Felipe Ribeiro

Abstract excerpt

Exposure to ionizing radiation greatly increases the risk of developing papillary thyroid carcinoma (PTC), especially during childhood, mainly due to gradual inactivation of DNA repair genes and DNA damages. Recent molecular characterization of PTC revealed DNA methylation deregulation of several promoters of DNA repair genes. Thus, epigenetic silencing might be a plausible mechanism for the activity loss of...

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Identifiers

PMID: 28574327
DOI: 10.1667/RR14532.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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