Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer Cells and Normal Cells Differ in Their Requirements for <i>Thoc1</i>

15 Jul 2007

Abstract excerpt

The evolutionarily conserved TREX (Transcription/Export) complex physically couples transcription, messenger ribonucleoprotein particle biogenesis, RNA processing, and RNA export for a subset of genes. HPR1 encodes an essential component of the S. cerevisiae TREX complex. HPR1 loss compromises transcriptional elongation, nuclear RNA export, and genome stability. Yet, HPR1 is not required for yeast viability....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Nuclear Structure and Function
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17638875
DOI: 10.1158/0008-5472.can-06-3234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer Cells and Normal Cells Differ in Their Requirements for <i>Thoc1</i>PMID 17638875Read ↗

Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.Semantic proximity Read ↗

Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Semantic proximity Read ↗

Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity.Semantic proximity Read ↗

Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p.Semantic proximity Read ↗

Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.Semantic proximity Read ↗

Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular CarcinomaSemantic proximity Read ↗

Mechanisms of mRNA processing defects in inherited <i>THOC6</i> intellectual disability syndromeSemantic proximity Read ↗

Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathwaySemantic proximity Read ↗

Pol II degradation activates cell death independently from the loss of transcriptionSemantic proximity Read ↗

The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.Semantic proximity Read ↗

Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.Semantic proximity Read ↗

Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.