Article
CYP2D6 genotyping in patients on psychoactive drug therapy.
Clinical chemistry and laboratory medicine - 1 Sept 2000
Topić E, Stefanović M, Ivanisević A M, Blazinić F, Culav J, Skocilić Z
Abstract excerpt
The polymorphic isoenzyme CYP2D6 has a major role in the oxidative metabolism of many deal of psychoactive drugs. Its six mutant alleles (null alleles *3, *4, *5, *6, *7 and *8) encode for inactive enzyme molecules. A carrier of two mutant alleles is considered a poor metabolizer phenotype, while...
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