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Article

Effect of Routine Cytochrome P450 2D6 and 2C19 Genotyping on Antipsychotic Drug Persistence in Patients With Schizophrenia: A Randomized Clinical Trial.

JAMA network open - 1 Dec 2020

Jürgens Gesche, Andersen Stig E, Rasmussen Henrik B, Werge Thomas, Jensen Heidi D, Kaas-Hansen Benjamin Skov, Nordentoft Merete

Abstract excerpt

Importance: Genetic polymorphism of genes encoding the drug metabolizing enzymes, cytochrome P450 2D6 and 2C19 (CYP2D6 and CYP2C19), is associated with treatment failure of and adverse reactions to psychotropic drugs. The clinical utility of routine CYP2D6 and CYP2C19 genotyping (CYP testing) is unclear. Objective: To estimate whether routine CYP testing effects the persistence of antipsychotic drug treatment....

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Identifiers

PMID: 33284338
DOI: 10.1001/jamanetworkopen.2020.27909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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