Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2D6 mutations and therapeutic outcome in schizophrenic patients.

Pharmacotherapy - 1 Sept 1999

Hamelin B A, Dorson P G, Pabis D, Still D, Bouchard R H, Pourcher E, Rail J, Turgeon J, Crismon M L

Abstract excerpt

STUDY OBJECTIVE: To investigate whether a relationship exists between the most common known cytochrome P450 (CYP) isozyme 2D6 mutations and schizophrenia. Because most antipsychotic and antidepressant agents interact with CYP2D6, we also investigated clinical outcomes in schizophrenic poor metabolizers (PMs) and extensive metabolizers (EMs). DESIGN: Prospective, observational study. SETTING: Two psychiatric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Cytochrome P-450 CYP2D6

Share to Isoenzymes

Share to Schizophrenia

Share to Treatment Outcome

Source

Identifiers

PMID: 10610012
DOI: 10.1592/phco.19.13.1057.31593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2D6 mutations and therapeutic outcome in schizophrenic patients.PMID 10610012Read ↗

CYP2D6 genotype predicts antipsychotic side effects in schizophrenia inpatients: a retrospective matched case-control study.Semantic proximity Read ↗

Does the medication pattern reflect the CYP2D6 genotype in patients with diagnoses within the schizophrenic spectrum?Semantic proximity Read ↗

Cyp2d6*3, *4, *5 and *6 polymorphisms and antipsychotic-induced extrapyramidal side-effects in patients receiving antipsychotic therapy.Semantic proximity Read ↗

Molecular diversity at the CYP2D6 locus in healthy and schizophrenic southern Brazilians.Semantic proximity Read ↗

CYP2D6 polymorphism: implications for antipsychotic drug response, schizophrenia and personality traits.Semantic proximity Read ↗

CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients.Semantic proximity Read ↗

Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype.Semantic proximity Read ↗

CYP 2D6 polymorphism and antipsychotic therapy.Semantic proximity Read ↗

CYP2D6 genotyping in patients on psychoactive drug therapy.Semantic proximity Read ↗

Low frequency of CYP2D6 poor metabolizers among schizophrenia patients.Semantic proximity Read ↗

Pharmacogenetics of Long-Term Outcomes of Schizophrenia Spectrum Disorders: The Functional Role of CYP2D6 and CYP2C19Semantic proximity Read ↗

The AmpliChip <sup>®</sup> CYP450 Test and Response to Treatment in Schizophrenia and Obsessive Compulsive Disorder: A Pilot Study and Focus on Cases with Abnormal CYP2D6 Drug MetabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.