Article
Familial chronic lymphocytic leukemia.
Seminars in oncology - 1 Apr 2006
Sellick Gabrielle S, Catovsky Daniel, Houlston Richard S
Abstract excerpt
The role of inherited genetic factors in the etiology of chronic lymphocytic leukemia (CLL) and other B-cell lymphoproliferative disorders (LPDs) is now well established. Significant familial aggregation of CLL and B-cell LPDs has been demonstrated, but the mode of inheritance is unknown. Identifying genes that when mutated confer an increased risk of these diseases is of immediate clinical relevance in terms of...
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