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Article

Epidermal growth factor receptor as a therapeutic target in human thyroid carcinoma: mutational and functional analysis.

The Journal of clinical endocrinology and metabolism - 1 Sept 2006

Mitsiades Constantine S, Kotoula Vassiliki, Poulaki Vassiliki, Sozopoulos Elias, Negri Joseph, Charalambous Elpida, Fanourakis Galinos, Voutsinas Gerassimos, Tseleni-Balafouta Sophia, Mitsiades Nicholas

Abstract excerpt

CONTEXT: The epidermal growth factor receptor (EGFR), a transmembrane tyrosine kinase (TK) receptor that mediates proliferation and survival signaling, is expressed in a wide variety of normal and neoplastic tissues. EGFR inhibitors have produced objective responses in patients with non-small-cell lung carcinomas harboring activating EGFR TK domain somatic mutations. OBJECTIVE AND METHODS: Because the EGFR...

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PMID: 16822827
DOI: 10.1210/jc.2006-0055

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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