Back to search

Article

Lestaurtinib’s antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancer

2024-06-09

Abstract excerpt

Ovarian cancer is the deadliest gynecological malignancy, owing to its late-stage diagnosis and high rates of recurrence and resistance following standard-of-care treatment, highlighting the need for novel treatment approaches. Through an unbiased drug screen, we identified the kinase inhibitor, lestaurtinib, as a potent antineoplastic agent for chemotherapy- and PARP-inhibitor (PARPi)-sensitive and -resistant ova...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
19339e53-886b-5636-9255-aca0572c66df
DOI
10.1101/2024.06.06.597753
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Lestaurtinib’s antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancerDOI 10.1101/2024.06.06.597753
Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies.Semantic proximity
STAT-3 Inhibitors: State of the Art and New Horizons for Cancer TreatmentSemantic proximity
Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic targetSemantic proximity
BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancerSemantic proximity
JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast CancerSemantic proximity
Co-targeting the PI3K-Akt pathway improves response to MEK inhibition in low-grade serous ovarian cancer cell linesSemantic proximity
A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical TranslationSemantic proximity
ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERKSemantic proximity
A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cellsSemantic proximity
High throughput screening identifies dasatinib as synergistic with trametinib in low grade serous ovarian carcinomaSemantic proximity
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.Semantic proximity
The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP InhibitionSemantic proximity
Select a neighboring publication to make it the new centre.