Article
Lack of direct association between EGFR mutations and ER beta expression in lung cancer.
Anticancer research - 1 Mar 2011
Onitsuka Takamitsu, Uramoto Hidetaka, Tanaka Fumihiro
Abstract excerpt
BACKGROUND: Positive expression of estrogen receptor (ER) beta is correlated with a favorable prognosis for patients with epidermal growth factor receptor (EGFR) mutations and predicts a good clinical outcome for patients with lung cancer after treatment with an EGFR-tyrosine kinase inhibitor (TKI), suggesting that it may be a candidate surrogate marker. The molecular mechanism underlying the apparent link...
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