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Article

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

18 Sept 2008

Abstract excerpt

BACKGROUND INFORMATION: TSEs (transmissible spongiform encephalopathies) are neurodegenerative disorders affecting humans and animals. PrP(Sc), a conformationally altered isoform of the normal prion protein (PrP(C)), is thought to be the pathogenic agent. However, the biochemical composition of the prion agent is still matter of debate. The potential transmission risk of the prion agent through biological fluids...

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PMID: 18422484
DOI: 10.1042/bc20080025

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