Article

Intercellular transmission of a bacterial cytotoxic prion-like protein in mammalian cells

2019-10-30

Abstract excerpt

RepA is a bacterial protein that builds intracellular amyloid oligomers acting as inhibitory complexes of plasmid DNA replication. When carrying a mutation enhancing its amyloidogenesis (A31V), the N-terminal domain (WH1) generates cytosolic amyloid particles that are inheritable within a bacterial lineage. Such amyloids trigger in bacteria a lethal cascade reminiscent to mitochondria impairment in human cells aff...

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Literature Corpus work: b6b3c344-9306-5855-b846-dc5975df5ce3
DOI: 10.1101/821215

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