Article
Multiple gene polymorphisms in the complement factor h gene are associated with exudative age-related macular degeneration in chinese.
Investigative ophthalmology & visual science - 1 Aug 2008
Ng Tsz Kin, Chen Li Jia, Liu David T L, Tam Pancy O S, Chan Wai Man, Liu Ke, Hu Yi Jun, Chong Kelvin K L, Lau Charles S L, Chiang Sylvia W Y, Lam Dennis S C, Pang Chi Pui
Abstract excerpt
PURPOSE: Variants in the complement factor H (CFH) gene have been shown to be strongly associated with age-related macular degeneration (AMD). In this study, sequence alterations in CFH were investigated in 163 Chinese patients with exudative AMD and 155 unrelated Chinese control subjects. METHODS: All the 22 CFH exons, intron-exon boundaries, and promoter sequences were screened by polymerase chain reaction and...
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