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Article

The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish.

BMC developmental biology - 17 Apr 2008

Hawkins Thomas A, Cavodeassi Florencia, Erdélyi Ferenc, Szabó Gábor, Lele Zsolt

Abstract excerpt

BACKGROUND: Key molecules involved in notochord differentiation and function have been identified through genetic analysis in zebrafish and mice, but MEK1 and 2 have so far not been implicated in this process due to early lethality (Mek1-/-) and functional redundancy (Mek2-/-) in the knockout animals. RESULTS: Here, we reveal a potential role for Mek1/2 during notochord development by using the small molecule...

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Identifiers

PMID: 18419805
DOI: 10.1186/1471-213X-8-42
PMCID: PMC2359734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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