Phenotypic analysis of a novel chordin mutant in medaka.

doi:10.1002/dvdy.21245

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Article

Phenotypic analysis of a novel chordin mutant in medaka.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2007

Takashima Shigeo, Shimada Atsuko, Kobayashi Daisuke, Yokoi Hayato, Narita Takanori, Jindo Tomoko, Kage Takahiro, Kitagawa Tadao, Kimura Tetsuaki, Sekimizu Koshin, Miyake Akimitsu, Setiamarga Davin H E, Murakami Ryohei, Tsuda Sachiko, Ooki Shinya, Kakihara Ken, Hojo Motoki, Naruse Kiyoshi, Mitani Hiroshi, Shima Akihiro, Ishikawa Yuji, Araki Kazuo, Saga Yumiko, Takeda Hiroyuki

Abstract excerpt

We have isolated and characterized a ventralized mutant in medaka (the Japanese killifish; Oryzias latipes), which turned out to have a mutation in the chordin gene. The mutant exhibits ventralization of the body axis, malformation of axial bones, over-bifurcation of yolk sac blood vessels, and laterality defects in internal organs. The mutant exhibits variability of phenotypes, depending on the culture...

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PMID: 17654721
DOI: 10.1002/dvdy.21245

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