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Article

Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma.

Molecular vision - 1 Jan 2011

Gregory-Evans Cheryl Y, Moosajee Mariya, Shan Xianghong, Gregory-Evans Kevin

Abstract excerpt

PURPOSE: We recently demonstrated that molecular therapy using aminoglycosides can overcome the underlying genetic defect in two zebrafish models of ocular coloboma and showed abnormal cell death to be a key feature associated with the optic fissure closure defects. In further studies to identify molecular therapies for this common congenital malformation, we now examine the effects of anti-apoptotic compounds in...

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PMID: 21677791
PMCID: PMC3110494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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