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Article

Alloreactivity: the Janus-face of hematopoietic stem cell transplantation

8 Mar 2017

Abstract excerpt

Differences in major and minor histocompatibility antigens between donor and recipient trigger powerful graft-versus-host reactions after allogeneic hematopoietic stem cell transplantation (HSCT). The clinical effects of alloreactivity present a Janus-face: detrimental graft-versus-host disease increases non-relapse mortality, beneficial graft-versus-malignancy may cure the recipient. The ultimate consequences on...

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PMID: 28270691
DOI: 10.1038/leu.2017.79

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