Article

Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens

2022-08-12

Abstract excerpt

Genome-wide genetic screens are powerful tools to identify genes that act as host factors of viruses. We have applied this technique to the analyze the infection of HeLa cells by Vaccinia virus, in an attempt to find genes necessary for infection. Infection of cell populations harboring single gene inactivations resulted in no surviving cells, suggesting that no single gene knock-out was able to provide complete r...

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Literature Corpus work: 60dd5d22-035a-5a4f-8bb9-47cc40f4af63
DOI: 10.1101/2022.08.10.503559

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