Article
A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.
Molecular pain - 16 Apr 2008
Wang Chenguang, Cheng Yun, Liu Tian, Li Qin, Fillingim Roger B, Wallace Margaret R, Staud Roland, Kaplan Lee, Wu Rongling
Abstract excerpt
Understanding differences in the genetic architecture of complex traits between the two sexes has significant implications for evolutionary studies and clinical diagnosis. However, our knowledge about sex-specific genetic architecture is limited largely because of a lack of analytical models that can detect and quantify the effects of sex on the complexity of quantitative genetic variation. Here, we derived a...
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