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<i>piggyBac</i> Transposon/Transposase System to Generate CD19-Specific T Cells for the Treatment of B-Lineage Malignancies

11 Nov 2009

Abstract excerpt

In this report, transposition with the piggyBac system is used to introduce a chimeric antigen receptor (CAR) into T lymphocytes. The CD19-specific CAR is expressed long term in expanding T cell populations from its integrated locus and leads to CD19-dependent killing of tumor targets. Chromosomal analysis indicated no signs of genotoxicity. Nonviral integrating vectors can be used for expression of therapeutic...

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PMID: 19905893
DOI: 10.1089/hum.2009.114

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