Article

Non-Viral Engineering of CAR-NK and CAR-T cells using the <i>Tc Buster</i> Transposon System™

2021-08-04

Abstract excerpt

Cancer immunotherapy using T cells and NK cells modified with viral vectors to express a chimeric antigen receptor (CAR) has shown remarkable efficacy in treating hematological malignancies in clinical trials. However, viral vectors are limited in their cargo size capacity, and large-scale manufacturing for clinical use remains complex and cost prohibitive. As an alternative, CAR delivery via DNA transposon engine...

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Literature Corpus work: c40ff699-3278-5ef7-9f66-fd45b8276c0e
DOI: 10.1101/2021.08.02.454772

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