Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WISP1 inhibition of YAP phosphorylation drives breast cancer growth and chemoresistance via TEAD4 activation

6 Jan 2025

Abstract excerpt

Wnt1-inducible signaling pathway protein 1 (WISP1) promotes breast cancer. The Hippo signaling pathway demonstrates a potential connection with WISP1, necessitating an exploration of their interaction. This study hypothesized that WISP1 boosts breast cancer by modulating the Hippo signaling pathway. The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were used to analyze WISP1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Hippo pathway signaling and YAP/TAZ
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39774151
DOI: 10.1097/cad.0000000000001687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WISP1 inhibition of YAP phosphorylation drives breast cancer growth and chemoresistance via TEAD4 activationPMID 39774151Read ↗

Implications for precision medicine and the reciprocal control of microRNAs by Hippo and TAZ signaling in breast cancerSemantic proximity Read ↗

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the <i>Drosophila Hippo</i> PathwaySemantic proximity Read ↗

WBP2 Negatively Regulates Hippo Pathway By Competitively Binding To WWC3 With LATS1 To Promote The Malignant Phenotype Of Non-Small Cell Lung CancerSemantic proximity Read ↗

Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune EvasionSemantic proximity Read ↗

Hippo pathway effectors YAP, TAZ and TEAD are associated with EMT master regulators ZEB, Snail and with aggressive phenotype in phyllodes breast tumors.Semantic proximity Read ↗

RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axisSemantic proximity Read ↗

Oncogenic Hedgehog-Smoothened Signaling Depends on YAP1‒TAZ/TEAD Transcription to Restrain Differentiation in Basal Cell CarcinomaSemantic proximity Read ↗

Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187Semantic proximity Read ↗

WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer CellsSemantic proximity Read ↗

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.Semantic proximity Read ↗

CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27Kip1 via Skp2 and FOXO3a regulationSemantic proximity Read ↗

The WISP1/Src/MIF Axis Promotes the Malignant Phenotype of Non-Invasive Breast Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.