Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Small RNA combination therapy for lung cancer.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2014

Xue Wen, Dahlman James E, Tammela Tuomas, Khan Omar F, Sood Sabina, Dave Apeksha, Cai Wenxin, Chirino Leilani M, Yang Gillian R, Bronson Roderick, Crowley Denise G, Sahay Gaurav, Schroeder Avi, Langer Robert, Anderson Daniel G, Jacks Tyler

Abstract excerpt

MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering miRNA mimics and siRNAs to lung adenocarcinoma cells in vitro and to tumors in a genetically engineered mouse model of lung cancer based on activation of oncogenic Kirsten rat sarcoma viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA, Small Interfering
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Combined Modality Therapy

Share to MAP Kinase Signaling System

Share to Nanoparticles

Share to Nanotechnology

Share to ras Proteins

Share to RNA, Neoplasm

Source

Open in PubMed Open full text

Identifiers

PMID: 25114235
DOI: 10.1073/pnas.1412686111
PMCID: PMC4151750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Small RNA combination therapy for lung cancer.PMID 25114235Read ↗

Overcoming multiple drug resistance in lung cancer using siRNA targeted therapySemantic proximity Read ↗

Potential Molecular Targets in the Treatment of Lung Cancer Using siRNA Technology.Semantic proximity Read ↗

“Non-viral CRISPR/Cas9 Mutagenesis for Streamlined Generation of Mouse Lung Cancer Models.”Semantic proximity Read ↗

Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer.Semantic proximity Read ↗

Cationic lipid-assisted polymeric nanoparticle mediated GATA2 siRNA delivery for synthetic lethal therapy of KRAS mutant non-small-cell lung carcinoma.Semantic proximity Read ↗

Advancements in gene therapy for lung cancer: from genetic insights to clinical applicationsSemantic proximity Read ↗

A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation.Semantic proximity Read ↗

siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma.Semantic proximity Read ↗

MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer.Semantic proximity Read ↗

microRNA-34a sensitizes lung cancer cell lines to DDP treatment independent of p53 status.Semantic proximity Read ↗

Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastasis lung cancerSemantic proximity Read ↗

Inhaled Gold Nano‐Star Carriers for Targeted Delivery of Triple Suicide Gene Therapy and Therapeutic MicroRNAs to Lung Metastases: Development and Validation in a Small Animal ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.