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Article

Ribonucleotide Reductase Inhibition Triggers Ferroptosis in Genetically Defined Subsets of Non-Small Cell Lung Cancer.

Cancer research communications - 1 Sept 2026

Sen Utsav, Natour Dalia, Chakraborty Subhamoy, Gobbini Elisa, Fan Chih-Wei, Koelbel Calvin, Elliott Andrew, Vanderwalde Ari M, Borghaei Hossein, Halmos Balazs, Demircioglu Deniz, Hasson Dan, Gandhi Nishant, Sen Triparna

Abstract excerpt

Non-small cell lung cancer (NSCLC) is responsible for the majority of cancer-related mortality worldwide. Lung adenocarcinoma is the most common NSCLC subtype. Despite advances in targeted therapies, treatment resistance remains a critical challenge. Ribonucleotide reductase (RNR), a crucial enzyme in deoxyribonucleotide triphosphate biosynthesis, is frequently upregulated in cancer, contributing to genomic...

Read the complete abstract on PubMed

Topics

Humans
Lung Neoplasms
Ferroptosis
Carcinoma, Non-Small-Cell Lung
Ribonucleoside Diphosphate Reductase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Ribonucleotide Reductases

Animals

Cell Line, Tumor

DNA Damage

Mice

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42664521
DOI: 10.1158/2767-9764.CRC-25-0829
PMCID: PMC13564884

Genes

RRM1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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